Coronavirus Tidbits #200 7/10/22
Announcements:
First, there is now a Resources Page here for the most commonly asked questions I'm getting.
Happy to continue to answer your questions/concerns as best I can, so don't be shy about that.
News
Covid:
Emerging omicron subvariants BA.2.12.1, BA.4 and BA.5 are inhibited less efficiently by antibodies
most of the therapeutic antibodies available for treatment of COVID-19 patients do not inhibit BA.2.12.1, BA.4, and BA.5 at all or only inhibit with reduced potency.
The antibody Bebtelovimab constitutes the only exception, since this antibody blocked all tested variants with high efficiency.
https://medicalxpress.com/
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Persistent spike protein could be a biomarker of long Covid, small study says
STAT July 8, 2022
One of the main theories to explain what causes long Covid is viral persistence, or the continued presence of some part of the coronavirus in the body long after the acute infection ends. (Another, possibly overlapping hypothesis for lingering symptoms posits an overactive immune response that turns into an autoimmune attack on the body’s organs.) Now a new study reports the discovery of the SARS-CoV-2 spike protein circulating in the blood of more than half of long Covid patients up to 12 months after being diagnosed with an active infection.
That suggests the presence of an active persistent SARS-CoV-2 viral reservoir, the researchers conclude. There are caveats: The study was small, in 63 patients, and it’s a preprint, so it has not been peer-reviewed. But the researchers say this builds on their previous work on a rare Covid complication in children and could represent a biomarker to help diagnose and treat people with long Covid.
https://mailchi.mp/statnews/tk-tncyc6de8v-617588?e=5c09ee46b1
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WASHINGTON (AP) — Pharmacists can prescribe the leading COVID-19 pill directly to patients under a new U.S. policy announced Wednesday that’s intended to expand use of Pfizer’s drug Paxlovid.https://t.co/vdQM9Dk5C0
— Zeke Miller (@ZekeJMiller) July 6, 2022
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https://twitter.com/KatieKlocksin/status/1545551164875350021?s=20
Monkeypox
Study shows virus isolates on surfaces
Yesterday in Eurosurveillance, researchers reported that environmental sampling from the hospital rooms of two recovered monkeypox patients in Germany showed isolated virus on surfaces, particularly those touched by patients' hands. The highest levels were found in bathrooms, and high loads were also seen on chair seats and on the touch screen of one patient's phone.
"Contaminated surfaces with such viral loads or higher, could potentially be infectious and it cannot be ruled out that their contact with especially damaged skin or mucous membranes, could result in transmission," the authors concluded.
The monkeypox outbreak has grown significantly in Europe, with cases tripling over the past 2 weeks. Today, World Health Organization Regional Director for Europe, Hans Henri P. Kluge, MD, called on member states to ramp up surveillance programs to detect cases.
Though 99% of Europe’s 4,500 cases have been in adult males, Kluge said, "Small numbers of cases have also now been reported among household members, heterosexual contacts, and non-sexual contacts as well as among children."
Ten percent of European cases have required hospitalization, but no deaths have been reported.
https://www.cidrap.umn.edu/news-perspective/2022/07/new-york-illinois-get-doses-monkeypox-vaccine
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Monkeypox #s. : now 605 cases in the US. New York has the most cases, with 122, followed by California with 116 and Florida with 64. Global cases of the virus increased 77% in the past week.
41% of patients HIV-positive; 60% (1,214 of 2,025) identified as gay, bisexual, and other men who have sex with men.
The WHO also warned that 25 cases have been detected so far among healthcare workers, and said transmission in this setting cannot be ruled out.
The global total stands at 6,027 cases from 59 countries.
https://www.cidrap.umn.edu/
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https://twitter.com/benryanwriter/status/1545034227120472064?s=20&t=ie2kRwozTXTw_NJ7wSZT-w
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https://twitter.com/HelenBranswell/status/1543969426705420290?s=20
Polio
What polio's UK presence means for global health
A form of polio derived from the vaccine is likely circulating in the UK, highlighting the ongoing need for polio vaccination worldwide.
a poliovirus strain was detected during routine surveillance of wastewater in February. A mutated version of the same strain was picked up again in the following months, the agency added, suggesting the virus has spread between individuals, allowing it to evolve.
This virus is called ‘vaccine-derived’ poliovirus. It is so-called because it is a strain of (weakened) poliovirus that would have originally been found in oral polio vaccines, but has changed over time to behave more like a 'wild' type, or naturally-occurring poliovirus. Vaccine-derived poliovirus can spread through faeces or respiratory secretions. On rare occasions it can infect the nervous system, causing paralysis and breathing problems in unvaccinated people.
https://www.nature.com/
Enteric (Norovirus) Viruses Shown Capable of Spreading via Saliva
...The transmission of these so-called enteric viruses through saliva suggests that coughing, talking, sneezing, sharing food and utensils, and even kissing all have the potential for spreading the viruses. The new findings “Enteric viruses replicate in salivary glands and infect through saliva,” which still need to be confirmed in human studies, appear in Nature. The researchers believe their discovery could lead to better ways to prevent, diagnose, and treat diseases caused by these viruses, potentially saving lives. The study was led by the National Heart, Lung, and Blood Institute (NHLBI), part of NIH.
Diagnostics:
Skin Patch Test Detects COVID-19 in Under Three Minutes
A rapid and reliable skin-patch test can now detect the COVID-19 virus, and potentially other infectious agents in under three minutes, without the need to draw blood. This convenience overcomes a current challenge in identifying infected individuals who are averse to blood tests and could help restrict the spread of the pandemic.
The details of the new test were published on July 1, 2022, in an article in the journal Scientific Reports titled, “Anti‑SARS‑CoV‑2 IgM/IgG antibodies detection using a patch sensor containing porous microneedles and a paper‑based immunoassay.”
Drugs and Vaccines
COVID-19 Vaccines for People who are Moderately or Severely Immunocompromised | CDC
— Drew Lewis (@drewlewismd) July 4, 2022
A reminder that 3 doses is the primary series and then 2 booster doses to be fully vaccinated.
A total of 5 shots for immunocompromised. https://t.co/lIs4urZ2CG
If you are immunocompromised, get a 2nd booster
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We may need to space #COVID19 #vaccine doses further apart because, "neutralizing antibody titers increased" w/more months between the 2nd & 3rd doses. "In vaccinees who had an interval of 4 to 6 mos betn doses...titers were higher by factor of 10"https://t.co/vSjijCnE4F
— Laurie Garrett (@Laurie_Garrett) July 7, 2022
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Whopping Mortality Benefit in Severe #COVID Trial https://t.co/xGp7C8f8Ar #sabizabulin
— Judy Stone (@DrJudyStone) July 9, 2022
Devices and Masks:
If you use a good mask like the Aura and you're not a healthcare worker you don't need a fit-test.
— Jeremy Howard (@jeremyphoward) July 8, 2022
Non-experts get an average fit factor of 88, well over the recommended goal of 10. (In healthcare the goal is 100, to provide a 10x safety margin.)https://t.co/5jc5gGiJOb
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On hotels, apartments:
If there are issues with any of this, notify the front desk.
— Joey Fox, P. Eng, M.A.Sc (@joeyfox85) June 8, 2022
Clean the air in the suite
Open windows and run a HEPA filter. It's best to place it near the door so you are filtering the air that is entering from the hallway.
5/8
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“Using a smoke machine, they studied airflow patterns in the school's five classrooms and administration areas.
— Nat K (@nathalie_k1) July 5, 2022
Carbon dioxide meters were also used to identify low-ventilation areas or "dead spots".
They then purchased HEPAs”https://t.co/fh3ecvh9DV
Epidemiology/Infection control:
https://twitter.com/ChristyCeeCK/status/1544496084139089923?s=20&t=RQd7rCUI3RXBYNpxhGylZw
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What to Know About the New BA.2.75 Omicron Subvariant https://t.co/9Vh0ByhxiM
— Judy Stone (@DrJudyStone) July 9, 2022
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As California’s COVID test positive rate nears record levels, the risk is higher in nearly all settings. “The chances of being around someone outside or inside who is shedding virus is very high.”@sfchronicle https://t.co/sTg97J92Fs
— Aidin Vaziri (@MusicSF) July 7, 2022
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How long do we Isolate⁉️
— WesElyMD (@WesElyMD) July 5, 2022
NEW DATA @NEJM
Only HALF of patients stop shedding #COVID (current wave) at day 5.
If 1 in 4 patients w #Omicron are still shedding culturable virus on day 9, why is @CDCgov still recommending stopping isolation at day 5?
https://t.co/blR8yJTBAH pic.twitter.com/HZACRzOzrd
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Today's @washingtonpost editorial on the BA.5 varianthttps://t.co/HLRpQSYBNG pic.twitter.com/eNm00RbBxE
— Eric Topol (@EricTopol) July 8, 2022
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The power of #SARSCoV2 wastewater sequencing to detect multiple important variants well before they are manifest clinicallyhttps://t.co/VNS1sycObv
— Eric Topol (@EricTopol) July 7, 2022
Just published @Nature @KnightLabNews @K_G_Andersen @smruthi_karthik @UCSanDiego @UCSDHealth @SanDiegoCounty pic.twitter.com/NN4c4eJWio
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Interesting that this blew up - it seemed like a simple aside to remind people that you can reduce your risk of infection by reducing your exposure. Swiss cheese model - testing, ventilation/filtration, masks - still works. Each layer lowers your risk.
— Jon Levy (@jonlevyBU) July 6, 2022
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Further evidence that even "mild" #COVID19 cases can lead to brain damage.... https://t.co/Tzhu8QfHLG
— Laurie Garrett (@Laurie_Garrett) July 3, 2022
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1. Now everyone can stop raising their eyebrows when I say that I exercise outdoors wearing an N95 mask. Omicron is a game-changer for transmissibility. BA.5 takes that to the next level. It's dead wrong to assume that outdoor transmission is insignificant https://t.co/UjAhb4XGG9
— Dr Satoshi Akima FRACP 『秋間聰』 (@ToshiAkima) July 2, 2022
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New @NEJM shows median time from symptom onset or PCR+, whichever was first, to culture conversion was 8 days (IQR 5-10).
— Emily R Smith, ScD MPH (@DrEmilyRSmith) July 7, 2022
In other words, about half of people with omicron are likely still contagious at day 8 or later (regardless of vaccine status).https://t.co/t3LoAhosSo pic.twitter.com/Ru9IHyNsNc
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1/ In our new paper, we describe lack of transmission from a very contagious healthcare worker during the Omicron surge caring for immunocompromised patients
— Abraar Karan (@AbraarKaran) July 7, 2022
Use of N95 respirator, excellent ventilation in hospital rooms & availability of testing all helped to avert more spread pic.twitter.com/VsW1CKNxFY
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Why is it the "worst variant" yet?
— Eric Topol (@EricTopol) July 8, 2022
Not because it causes worse disease. There is no evidence for that.
Because it is the most transmissible and most immune-evasive of any version of the virus since the pandemic began.https://t.co/vwK1ZXsU7m
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Researchers from Brigham and Women's Hospital say they have found the SARS-CoV-2 spike protein circulating in the blood of long COVID patients up to 12 months after they were diagnosed with COVID-19.
— The Boston Globe (@BostonGlobe) July 8, 2022
Here's what we know of their #LongCovid study findings. https://t.co/U0wutcalR4
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Who’s most at risk of developing #LongCOVID? Experts think these 6 groups of people might be, by @ErinMPrater https://t.co/C2OFhnUAWl via @FortuneMagazine @LongCovidGroup #COVID19
— André Picard (@picardonhealth) July 8, 2022
1 in 8 adults hospitalized for Covid have weakened immune systems
People with weakened immune systems caused by HIV, transplants, many cancers, or their treatments are more vulnerable to Covid-19 infection. A new CDC report estimates that 1 in 8 adults hospitalized for Covid from March 2020 through February 2022 were immunocompromised, and they had a higher risk of ICU admission and dying in the hospital compared to people with healthy immune systems. Being vaccinated helped keep immunocompromised people out of the hospital, but unlike people with healthy immune systems, once admitted, their vaccination status did not make a difference in ICU admission or death.
That seems puzzling, but the researchers say that patients with more medical conditions — and at higher risk for severe outcomes — likely had closer medical follow-up and were vaccinated, which would bias the numbers. The report strongly urges vaccination for patients and those around them, pre-exposure therapeutics such as Evusheld, early testing, and antivirals if they get sick.
https://mailchi.mp/statnews/tk-tncyc6de8v-617588?e=5c09ee46b1
Tips, general reading for public:
Ventilate.
Mask.
Vax.
Politics:
Covid:
https://twitter.com/EricTopol/status/1545449245028716544?s=20&t=ie2kRwozTXTw_NJ7wSZT-w
SCOTUS:
Has anyone but historians noticed that the two flagships associations for professional historians and 8 other societies of historians issued a statement that says the Supreme Court lied regarding the history facts of abortion and abortion law in USA
— Victor Hall (@therealVictorHa) July 7, 2022
Here is the Joint OAH-AHA Statement on the <i>Dobbs v. Jackson</i> D... | OAH oah.org/insights/posts
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NEW: Justice Brett Kavanaugh had to exit through the rear of Morton's on Wednesday night after DC protestors showed up out front. A Morton's rep told me: "Politics … should not trample the freedom at play of the right to congregate and eat dinner." https://t.co/wlA4J2nxYW pic.twitter.com/jpsfhB3JVo
— Daniel Lippman (@dlippman) July 8, 2022
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"He arranged over the years for about 20 couples to fly to Washington to visit with and entertain Supreme Court Justices Clarence Thomas, Samuel Alito and the late Antonin Scalia." https://t.co/EKkffa0bWz
— Kyle Griffin (@kylegriffin1) July 8, 2022
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EXCLUSIVE: Supreme Court justices "prayed with" these right-wing, evangelical activists — then cited them to overturn Roe v. Wade https://t.co/Edrqj2HLiw
— Noah Shachtman (@NoahShachtman) July 6, 2022
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Separation of Church:
Your reminder that if you see a sign in front of a church about politics you can report them to the IRS.
— Freesus Patriot™ (@CGSDemocracy) July 4, 2022
You're welcome. https://t.co/xhbHajokHV
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https://twitter.com/jbendery/status/1544718677215510528?s=20
Jan 6
A retired General, fired as Nat. Security Advisor for lying to the Vice President, plead guilty to lying to the FBI, and recently took the 5th when asked if he believes in an orderly transfer of power..
— Les LeMieux, Sr (@leslsenior) July 8, 2022
Is still receiving a Military retirement pension paid for by our tax dollars
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Women/Abortion:
12 years ago, when I first told my GP I was pregnant she was sitting in a swivel chair typing and just spun it round to face me and said ‘And is that good news?’
— Crappy Living (@crappyliving) July 3, 2022
It was, for me, but with one sentence I knew all options were there without judgement - have thought about that a lot
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https://twitter.com/sadgorlzai/status/1544072032106823689?s=20
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https://twitter.com/Miriam2626/status/1544837234595139584?s=20
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I'm 67. I lived through these years. Young women don't know a world pre-Roe. They never knew days when we couldn’t buy a car or get a credit card without a man co-signing. They don’t know times when we weren’t allowed to wear pants. It is our duty to inform them. #DemVoice1 pic.twitter.com/NWPSUMIoOG
— Jaye T. (@JayeJaybird54) July 3, 2022
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1/ Last week’s U.S. Supreme Court decision ending the constitutional protection for abortion closed the doors to one of Mississippi’s last clinics.
— Texas Tribune (@TexasTribune) June 29, 2022
Its executive director, Shannon Brewer, is relocating the clinic to New Mexico to continue providing care.https://t.co/yO6W0WqafQ
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https://twitter.com/QasimRashid/status/1543342545656242176?s=20
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I live in Virginia. I’m on low-dose naltrexone as an off-label treatment for long Covid to reduce clotting. My pharmacy won’t refill my Rx because it can cause miscarriage.
— Oyez Cómo Va, Esq. (@FemiYahtzee) July 4, 2022
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There is no "delivering a baby who is ectopic," @nytimes. It is not possible. There is no scenario in which a "baby" exists at the end of an ectopic pregnancy; the natural course is a clump of cells and a dead woman.
— Max Kennerly (@MaxKennerly) July 5, 2022
Might as well talk about "delivering ovarian cancer." pic.twitter.com/jrnm97sQFd
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Be this person pic.twitter.com/SlI9NWYsaU
— Vicster (@ConnoVicster) July 4, 2022
GOP:
Mitch McConnell claims gas prices are high because Biden’s waging “a holy war against American fossil fuels.”
— John Nichols (@NicholsUprising) July 5, 2022
Actually, prices are high because of oil company price gouging. And when the House voted to crack down on it, McConnell BLOCKED Senate action.
https://t.co/w7lYDlVlUT
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As highly visible and politicized book bans have exploded across the country, librarians have found themselves on the front lines of an acrimonious culture war, with their careers and their personal reputations at risk. https://t.co/cXlFxZ0FlU
— New York Times Books (@nytimesbooks) July 7, 2022
Guns:
Justice Clarence Thomas once opposed Highland Park's assault weapons ban, saying that the 'overwhelming majority' of those with the rifles use them lawfully https://t.co/gBkb9C9uUM
— Matt Murphy (@MattMurph24) July 5, 2022
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According to the Highland Park press conference, in 2019 the suspect threatened to kill people and had his "knife collection" removed. So why was he able to "legally" purchase five firearms a year ago? #twill
— Shannon Watts (@shannonrwatts) July 5, 2022
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The only reason you’re celebrating Independence Day is because citizens were armed. #FourthofJuly
— NRA (@NRA) July 4, 2022
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https://twitter.com/GunOwners/status/1543973121451036674?s=20
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"If you don't own a gun, you don't know enough about them to make gun laws," he says just after regulating a uterus.
— Steve Hofstetter (@SteveHofstetter) July 5, 2022
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When President Clinton banned assault rifles in 1994, mass shootings dropped by 43%. After Republicans let the ban expire in 2004, they increased by 243%, these numbers tell a story.
— Academic Radio (@academicviews) July 5, 2022
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Holy crap. Rep. Debbie Lesko (R-AZ) said she would shoot her own grandchildren to oppose a gun safety reform bill that would keep guns out of the hands of those who should not have them. (h/t @RyanShead) pic.twitter.com/LSOuI0jDif
— No Lie with Brian Tyler Cohen (@NoLieWithBTC) July 6, 2022
Race:
Last month, the group intended to riot at a Pride event in Idaho. Last weekend, they stormed through the streets of Boston.
— Here & Now (@hereandnow) July 7, 2022
Patriot Front, a neo-Nazi group, is gaining traction and contributing to the larger white supremacy movement. https://t.co/sRrax5J5qx
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When women showed up at the Supreme Court to express our grief over the end of Roe, heavily armed police quickly surrounded the area & there were snipers on the roof of SCOTUS
— Lindy Li (@lindyli) July 3, 2022
Today nearly 100 Patriot Front terrorists marched through Boston
Police were seen PROTECTING them
WTF
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Adolf Eichmann - architect of the Holocaust - admits to devising the Nazi Final Solution in unearthed tapes
— Daily Mail Online (@MailOnline) July 5, 2022
Full story: https://t.co/aLsibs2XHJ pic.twitter.com/MfQFHi40dP
Pennsylvania:
https://twitter.com/RonFilipkowski/status/1543672068033679361?s=20
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Pa. Senate GOP committee advances late-night constitutional amendment to say residents do not have 'any rights relating' to abortion, require voter ID https://t.co/dX4UVxRENU
— Gillian McGoldrick (@gill_mcgoldrick) July 8, 2022
Virginia:
BREAKING: Over 300 Virginia Government employees have RESIGNED in the wake of Youngkin taking away their virtual work option - something they were told was never gonna be reversed.
— Ethan Lynne (@ethanclynne) July 8, 2022
California:
We’re about to celebrate Independence Day -- but Freedom is under attack by Republican leaders in states like Florida.
— Gavin Newsom (@GavinNewsom) July 3, 2022
Banning books.
Restricting speech.
Making it harder to vote.
Criminalizing women and doctors.
It’s time to stand up. Don’t let them take your freedom. pic.twitter.com/cFI5UzgZzX
Positioning himself for 2024?
Arizona:
I can think of other ways to cut down on recorded instances of police misconduct https://t.co/DQ3NJurLiL
— Drew Harwell (@drewharwell) July 8, 2022
Tennessee:
Just in case you missed it:
— Asian & Pacific Islanders (@MaricopaAAPI) July 6, 2022
Chancery Court in Davidson County, Tennessee, has ruled that taxpayer funded establishments can place signs that say "No Jews Allowed" ... as long as there is at least one establishment where services for Jews are provided. https://t.co/WkP0KGHysZ
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Can’t stop thinking about this link between rising rent & homelessness and the increasingly brutal efforts to remove unhoused people from public space.
— Brian Goldstone (@brian_goldstone) July 3, 2022
Two days ago Tennessee made it a class E felony to camp on public land. In Nashville, median rent is up *21.5%* since May 2021.
Mississippi:
This is a terrifying video. Not only did Judge Debbra K. Halford allow a Mississippi abortion trigger ban to go into effect today, she began the hearing with a Christian minister praying “Lord… We seek your truth, not our own.” pic.twitter.com/XSj9lj8l0U
— Guthrie Graves-Fitzsimmons (@GuthrieGF) July 6, 2022
Missouri:
US Senate candidate Eric Greitens is back with another ad shooting and blowing things up with his “army of patriots.” pic.twitter.com/5pwvq6PQUz
— Ron Filipkowski (@RonFilipkowski) July 6, 2022
Indiana:
True story:
— John Oberlin (@OMGno2trump) July 7, 2022
Republicans in Indiana had three choices and picked the guy in prison for murdering his wife with a flower pot and throwing her body off a bridge.
If you don't want people like this picking your congressman you better vote, and vote blue.
https://t.co/cBjtemCKIh
New Hampshire:
https://twitter.com/RonFilipkowski/status/1544291191965065217?s=20
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Florida:
— #GettheLeadOut #ScienceIsReal #TruthMatters (@SafeH2o4Schools) July 4, 2022
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A friend sends: "Florida is like Germany in 1933, only humid."
— Rick Wilson (@TheRickWilson) July 5, 2022
Ohio:
Ohio lawmaker wants to teach the Holocaust ‘from the perspective of the Nazis' https://t.co/wfuO32mwbL
— Judy Stone (@DrJudyStone) July 9, 2022
Feel good du jour:
Alaska family’s blind golden retriever found after being lost for three weeks https://t.co/3M9uRNmbeG
— Judy Stone (@DrJudyStone) July 9, 2022
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#NoPolitics Weekend. Call me maudlin. Call me sentimental. Call me an old fool. I don’t care. A reporter was doing a story about shelters dogs when this puppy came up to him and embraced the reporter and wouldn’t let go. The reporter did the only logical thing. He adopted him. pic.twitter.com/Dk5URK5KPc
— Jason Baum (@jasonbaum) July 3, 2022
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I spoke to Tom Barton, who wrote this priceless letter to the editor musing about the joys of sex. Spoiler alert: He's married. https://t.co/sSuU8uT0qp
— Gordon Russell (@GordonRussell1) July 7, 2022
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How a favela in Rio got its clean water back, for $42,300 https://t.co/YP9q2Crq5Z
— Judy Stone (@DrJudyStone) July 4, 2022
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This is the seamstress of the bird world…
— Mike Hudema (@MikeHudema) July 3, 2022
Nature is incredible. Protect it.#ActOnClimate #climate #energy #rewilding #birds pic.twitter.com/TgumRiLztg
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VIDEO A Mozambican park welcomes its first white rhinos in 40 years after 19 of the threatened animals completed a 1,600-kilometre truck ride from South Africa, conservationists said pic.twitter.com/KwXV9EnJk6
— AFP News Agency (@AFP) July 3, 2022
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https://twitter.com/WholesomeMeme/status/1544108803456647170?s=20
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Life cycle of the blackberry... pic.twitter.com/GePemAhurB
— Mark Stephens (@MarksLarks) July 6, 2022
Comic relief:
https://twitter.com/buitengebieden/status/1544358005705248768?s=20
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My 4th of July weekend plans are off to a good start pic.twitter.com/jFHt5JvHAA
— Dinty W. Moore (@brevitymag) July 3, 2022
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Mood.. pic.twitter.com/qa5PWL6Twz
— Buitengebieden (@buitengebieden) July 8, 2022
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https://twitter.com/buitengebieden/status/1545137924416671745?s=20
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https://twitter.com/buitengebieden/status/1545740159374729216?s=20
Perspective/Poem
On Independence Day, a uniquely American holiday, the most uniquely American thing happened today, a mass shooting.
— Fred Guttenberg (@fred_guttenberg) July 5, 2022