Coronavirus Tidbits #99 11/29/20
Quick links
News Diagnostics Drugs Devices Epidemiology/Infection control Tips Politics Feel good du jour Comic relief Perspective/Poem Bits of beauty
Announcements:
First, there is now a Resources Page here for the most commonly asked questions I’m getting.
Happy to continue to answer your questions/concerns as best I can, so don’t be shy about that.
News
Outrageous, unscientific, and unsurprising decision from the stacked Supremes, undermining public health during the middle of a pandemic:
Supreme Court on 5-4 vote blocks NY Gov. Cuomo from reimposing strict capacity caps on Catholic churches and synagogues that sued. Barrett joins conservative wing in majority; Roberts joins liberals in dissent.
Judge Kagan doesn’t normally join Justice Sotomayor’s blazing dissents, which were often solo or joined by Justice Ruth Bader Ginsburg.
— Cristian Farias (@cristianafarias) November 26, 2020
She does so here, which marks a shift for her. The two New Yorkers on the Supreme Court, one Jewish and the other Catholic, find common ground: pic.twitter.com/kG5YIw4XH4
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Thoughtful perspective from Pope Francis
And I think @pontifex has something to say on the moral argument. Not all people of faith are as anti-science as those on #SCOTUS. 11/ https://t.co/FdHx8b7mGs
— Gregg Gonsalves (@gregggonsalves) November 27, 2020
Pope Francis: “…
With some exceptions, governments have made great efforts to put the well-being of their people first, acting decisively to protect health and to save lives. The exceptions have been some governments that shrugged off the painful evidence of mounting deaths, with inevitable, grievous consequences. But most governments acted responsibly, imposing strict measures to contain the outbreak.
Yet some groups protested, refusing to keep their distance, marching against travel restrictions — as if measures that governments must impose for the good of their people constitute some kind of political assault on autonomy or personal freedom! Looking to the common good is much more than the sum of what is good for individuals. It means having a regard for all citizens and seeking to respond effectively to the needs of the least fortunate.
It is all too easy for some to take an idea — in this case, for example, personal freedom — and turn it into an ideology, creating a prism through which they judge everything…
…We cannot return to the false securities of the political and economic systems we had before the crisis. We need economies that give to all access to the fruits of creation, to the basic needs of life: to land, lodging and labor. We need a politics that can integrate and dialogue with the poor, the excluded and the vulnerable, that gives people a say in the decisions that affect their lives. We need to slow down, take stock and design better ways of living together on this earth.”
Sadly ironic how the Catholics on the Supremes are demonstrating the antithesis of what their Pope counsels.
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For those who have lost loved ones — I know this time of year is especially difficult. I will be thinking and praying for each and every one of you at your Thanksgiving table. pic.twitter.com/xlvaCrA1ZT
— Joe Biden (@JoeBiden) November 25, 2020
Diagnostics:
still an incredible, negligent lack of testing.
For those who like gifs, an explanation of RT-PCR by Ian Mackay starts here:
https://twitter.com/MackayIM/status/1331440271716827137?s=20
Drugs:
For everybody worried that RNA vaccines are now tested for the first time in humans. That is actually not the case. See list below. It is true that there is little long term safety data. But its not true that there is no long term safety data. pic.twitter.com/LrnzJvo42a
— Florian Krammer (@florian_krammer) November 26, 2020
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A reasonable response to AstraZeneca’s hype:
Please give the penicillin-proves-the-importance-of-serendipity-in-science bullshit a rest.
— Carl T. Bergstrom (@CT_Bergstrom) November 25, 2020
Letting mold grow on a plate is a hell of a lot different from injecting 2700 people with the wrong dose of an experimental treatment.
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https://twitter.com/alvie_barr/status/1332000729549180929?s=20
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Interesting hypothesis from Eli Perencevich:
Re: AstraZeneca-University of Oxford vaccine
— Eli Perencevich, MD MS (@eliowa) November 26, 2020
One word could explain the differential results: Blinding
Blinding is allocation concealment in a randomized trial, such that the recipient of the vaccine (and others) don't know whether they received the vaccine or placebo 1/6
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Convalescent #Plasma Flops for Severe #COVID19 — Randomized trial finds no benefit in clinical status or mortality vs placebo https://www.medpagetoday.com/infectiousdisease/covid19/89878?
Devices:
Courtesy of Republicans and anti-maskers:
We made the NYTimes! Per capita, Allegany County, where Cumberland is the county seat, now has the worst outbreak in Maryland, and that region has the 14th-highest number of recent cases per capita of any metro area in the country. https://t.co/TnqJpRfhUV Awaiting leadership
— Judy Stone (@DrJudyStone) November 25, 2020
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A Pew Research Center study in August found a 16-point gap between Democrats and Republicans on wearing masks in public settings.
Mask defiance remains strong in Big Sky Country, even as the pandemic rages
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New study from Linsey Marr
Preprint now at https://medrxiv.org/content/10.1101/2020.11.18.20233353v1… Take-home: Cloth masks are not an N95, but they work reasonably well for aerosols 1-2 microns and larger, which is the size that we think mostly mediates transmission.
For better performance, we recommend 3-layer mask w/ outer layers of tightly woven fabric + inner layer of something designed to filter aerosols. Should produce overall efficiency of >70% at the most penetrating particle size and >90% for >1 micron if the mask fits well. /5
https://vtnews.vt.edu/articles/2020/11/eng-marrmasks-1123.html
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COVID’s collateral damage: Germicidal lamps may damage corneas
In a paper published in the journal of Ocular Immunology and Inflammation – reported that several patients using germicidal lamps in an attempt to sanitize against the coronavirus, developed painful inflammation of the cornea, a condition called photokeratitis. These consumer-available ultraviolet (UV) emitting devices were being used in an attempt to eliminate coronavirus from homes and offices.
https://www.eurekalert.org/pub_releases/2020-11/uomm-ccd112420.php
Epidemiology/Infection control:
Superspreading:
— Kai Kupferschmidt (@kakape) November 25, 2020
The paper confirms previous work showing high overdispersion (so small minority of people leading to most onward transmission): “We find that 80% of secondary infections can be traced back to 15% of #SARSCoV2 infected individuals”.
Estimate k at 0.3 pic.twitter.com/BOrVle3lkW
Study from Hunan: https://science.sciencemag.org/content/early/2020/11/23/science.abe2424.full
Transmission risk: Authors found household contacts at highest risk, then extended family, then social and community contacts. Healthcare contacts were lowest risk.
Presymptomatic spread: They estimate that 63% of transmission came before symptoms. “Notably, we find that #SARSCoV2 infectiousness peaks slightly before symptom onset (-0.1 days on average), with 87% of the overall infectiousness concentrated within ±5 days of symptom onset and 53% of the overall infectiousness in the pre-symptomatic phase.”
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COVID-19 outbreak forces world's largest latex glove maker to shut factories after more than 2,400 workers infected https://t.co/m3IAcQI33h pic.twitter.com/cXjKZ2s8FL
— Eyewitness News (@ABC7NY) November 25, 2020
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South Dakota hits COVID milestone: 1 out of every 1,000 residents dead.
Same in Illinois: 1/1000 dead.
North Dakota 1/850 residents has died.
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U.S Coronavirus cases:
— Ali Velshi (@AliVelshi) November 27, 2020
Apr 28 – 1 Million
Jun 10 – 2 Million
Jul 7- 3 Million
Jul 23 – 4 Million
Aug 8 – 5 Million
Aug 30 – 6 Million
Sept 24 – 7 Million
Oct 15 – 8 Million
Oct 29 – 9 Million
Nov 8 – 10 Million
Nov 15 – 11 Million
Nov 21 – 12 Million
Nov 27 – 13 Million
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Thread: (starts here)
2/In many small hospitals there are no critical care, nephrology, gastroenterology docs on staff. There ER docs, hospitalists & maybe cardiology (real story). Hospitalists have to practice outside of their scope & they learn on the go.
— Natalia Solenkova, MD PhD (@SolNataMD) November 24, 2020
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Culture Shock: Why New Zealand’s Response to COVID-19 Worked
https://www.medpagetoday.com/blogs/working-stiff/89867
Tips, general reading for public:
StayAtHome
Wash your hands.
Rinse and repeat.
Politics:
The PA Supreme Court has dismissed the suit –with prejudice– that was attempting to throw out the votes of 2.5 million Pennsylvanians and halt certification.
“It is not our role to lend legitimacy to such transparent and untimely efforts to subvert the will of Pennsylvania voters. Courts should not decide elections when the will of the voters is clear.” – Justice Wecht, PA Supreme Court
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“This should be something for Georgians to celebrate, whether their favored presidential candidate won or lost. For those wondering, mine lost — my family voted for him, donated to him and are now being thrown under the bus by him.” #gapol https://t.co/oKdSGfyDvz
— Greg Bluestein (@bluestein) November 25, 2020
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Thinking tonight about Crystal Mason. A mother of 3. Now serving 5 years in prison for mistakenly voting while on probation & not knowing she wasn’t allowed to.pic.twitter.com/6lRxSUrWhc
— Scott Hechinger (@ScottHech) November 26, 2020
This might be the best political ad I've seen this year…. And it's for a Run-off https://t.co/dDvBn3bOzM
— Jason Johnson (@DrJasonJohnson) November 24, 2020
Feel good du jour:
Anyone need some beautiful fall colors right about now? pic.twitter.com/bxC0MIVg5I
— Sierra Club (@SierraClub) November 25, 2020
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Happiness, not in another place, but this place… not for another hour, but this hour.
— Felicity Plunkett (@FelicPlunkett) November 15, 2020
Walt Whitman, ‘A Song For Occupations’#waltwhitman
On Dharawal country pic.twitter.com/PrqiesRDSR
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Did my dog just pet my cat?? And did my cat just hug my dog??pic.twitter.com/6LFfdaHgBj
— Back To Nature (@backt0nature) November 28, 2020
Some of the comments are pretty funny, albeit snarky.
Comic relief:
Knitter Anne Eunson, who knitted a fence with twine based on a Shetland lace pattern, installed at the Shetland Textile Museum, Lerwick #womensart #KnitArt pic.twitter.com/JKjIzJUA77
— #WOMENSART (@womensart1) November 24, 2020
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Perspective/Poem
George Mason, delegate to Constitutional Convention, said in 1788 that a President should not have power to pardon because he might "pardon crimes which were advised by himself. It may happen, at some future day, that he will establish a monarchy, and destroy the republic."
— Michael Beschloss (@BeschlossDC) November 26, 2020
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https://twitter.com/MollyJongFast/status/1332465596722794498?s=20
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Each of us has a responsibility in our own lives to do what we can to slow the virus.
— Joe Biden (@JoeBiden) November 28, 2020
Every decision we make matters. Every decision we make can save a life. pic.twitter.com/Rm0bYqh6eH
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That you are fortunate enough
— Plague Poems (@PlaguePoems) November 27, 2020
not presently to be sick
does not mean
that you must pretend
to be well.
*
A compendium of the thirty-sixth week of plague poems…https://t.co/gHw6XvwkZE