Coronavirus Tidbits #231 2/5/23


First, there is now a Resources Page here for the most commonly asked questions I'm getting.

Happy to continue to answer your questions/concerns as best I can, so don't be shy about that.

Reminder, Resilience: One Family's Story... is increasingly pertinent, as some of our politicians shift rightward. All proceeds go to Holocaust education.

Available here.




Could a popular COVID-19 antiviral supercharge the pandemic?

Merck & Co.’s molnupiravir appears to be speeding evolution of SARS-CoV-2


A widely used COVID-19 drug may be driving the appearance of new SARS-CoV-2 variants, sparking concerns it could prolong and even reinvigorate the pandemic. The drug, molnupiravir, produced by Merck & Co., is designed to kill the virus by inducing mutations in the viral genome. A survey of viral genomes reported in a new preprint, however, suggests some people treated with the drug generate novel viruses that not only remain viable, but spread.

“It’s very clear that viable mutant viruses can survive [molnupiravir treatment] and compete [with existing variants],” says virologist William Haseltine, chair of ACCESS Health International, who has repeatedly raised concerns about the drug. “I think we are courting disaster.” But a Merck spokesperson disputes that the drug has led to the emergence of widely circulating variants, and some researchers downplayed the significance of molnupiravir-caused mutations. “Right now, it’s much ado about nothing,” says Raymond Schinazi, a medicinal chemist at the Emory University School of Medicine, noting that with SARS-CoV-2 infecting millions of people worldwide, the virus is naturally mutating at a fast clip.

Authorized in the United Kingdom and the United States in late 2021, molnupiravir was the first oral antiviral approved anywhere to fight COVID-19. It has since been authorized in dozens of other countries. In 2022, Merck estimated global sales of the compound at more than $5 billion. Though that is well below the $18.9 billion in 2022 sales for Paxlovid, another oral SARS-CoV-2 antiviral, molnupiravir remains widely popular in certain countries.

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Deer harbor out-of-circulation SARS-CoV-2 strains, study finds

Scientists analyzing samples collected from white-tailed deer in New York state have identified the Alpha, Gamma, and Delta SARS-CoV-2 variants well after they caused widespread COVID-19 in people, representing a reservoir for the strains and a potential future risk to humans.

The Cornell University researchers who conducted the study, published yesterday in Proceedings of the National Academy of Sciences, say it represents one of the most comprehensive approaches to date to assess the prevalence, genetic diversity, and evolution of SARS-CoV-2 in white-tailed deer.

March 2022 study by some of the same investigators and their colleagues found SARS-CoV-2 in up to 40% of deer populations across five states. And a December 2021 study led by Ohio State researchers found a 36% incidence in Ohio. The United States is home to an estimated 30 million white-tailed deer, the most abundant large animal in the country.

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COVID vaccine-boosted nursing home residents at 30% to 50% lower risk of infection

study today in Morbidity and Mortality Weekly Report finds that US nursing home residents who weren't up to date on recommended COVID-19 vaccines were at a 30% to 50% higher risk for infection than those who were current.

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The FDA eliminated the need for a positive COVID test before individuals can be prescribed Pfizer's nirmatrelvir co-packaged with ritonavir (Paxlovid) or Merck's molnupiravir (Lagevrio). (Reuters)
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Excellent overview from KFF on impact of ending the pandemic emergency plans will have:

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How quickly does COVID immunity fade? What scientists know

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Long Covid:

"Regarding #LongCovid...article from Germany a 43% higher chance of getting a new autoimmune disease after a Covid infection. This includes a 55% of new onset #Celiac 's disease after Covid infection, a 42 to 40% increase in #RheumatoidArthritis ... a 25% higher risk of getting Type I #Diabetes after a #Covid infection and a 28% higher risk of Crohn’s disease. The highest risks for new onset #autoimmune disease after a Covid infection were for autoimmune #vasculitis syndromes" 4/n  (source of citation not given)

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Other infections:

9 diseases that keep epidemiologists up at night

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UK reports more H5N1 avian flu in mammals

Tests on mammal species in the United Kingdom have found H5N1 avian influenza in red foxes and otters, according to notifications from UK animal health officials, part of a growing number of detections in mammals in Europe and the Americas.

The UK detections range from animals collected in 2021 through the early weeks of 2023. The animals that tested positive—five foxes and four otters—were from England, Scotland, and Wales.

Spanish officials recently reported H5N1 in farmed minks, and veterinary authorities in Canada and the United States have reported several H5N1 detections in wild mammals, including seals, raccoon, skunks, and bears.

The H5N1 clade circulating on multiple continents has a mutation that makes it more recognizable by human airway cells. So far only seven human infections have been reported, all in people who had close contact with sick poultry. Some were asymptomatic, but some were severe or fatal.

More avian flu also detected in poultry and wild birds

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Bobcat tests positive for avian influenza in Washington

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WHO continues global polio emergency-- and breach noted at Dutch vaccine facility

1 employee with an asymptomatic infection.

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Hogs are running wild in the U.S.—and spreading disease

National Geographic

Today, around six million feral swine run hog wild in at least 35 U.S. states, where they can grow more than five feet long and weigh more than 500 pounds. They’re adaptable creatures, capable of thriving in nearly any environment. For instance, the animals are also increasingly widespread on myriad Caribbean Islands and in Mexico, from the Baja to the Yucatán Peninsula, as well as Canada, where even deep snow and bitter cold can't slow them down. (Read how feral hogs are moving into Canada and building “pigloos.”)

 According to the USDA, feral swine can carry a litany of pathogens that could potentially spread to people such as leptospirosis, toxoplasmosis, brucellosis, swine influenza, salmonella, hepatitis, and pathogenic E. coli.

But there’s another concern—new diseases we don’t even know about yet.

“Swine, in general, are considered a mixing vessel species, because they’re susceptible to human viruses, like influenza viruses,” says Vienna Brown, a USDA staff biologist with the agency’s National Feral Swine Damage Management Program. “And when those get into swine,” she says, they could “create a novel influenza virus.”

By far, U.S. health officials are most worried about African swine fever, a virus that first originated in 1921 but has since reemerged in various countries worldwide. Though not transmissible to people, the disease is always fatal to pigs, either wild or farmed, says Brown.

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CDC investigating deadly outbreak of multidrug-resistant Pseudomonas tied to eye drops

The Centers for Disease Control and Prevention (CDC) is investigating a multistate outbreak of carbapenem-resistant Pseudomonas aeruginosa linked to eye drops and one death.

In a Jan 20 statement, the CDC said it identified 56 isolates of Verona integron-mediated metallo beta-lactamase and Guiana extended-spectrum beta-lactamase­–producing carbapenem-resistant P aeruginosa (VIM-GES-CRPA) from 50 case patients in 11 states from May 17, 2022, to Jan 19. Thirty-eight cases are part of four facility clusters. Whole-genome sequencing data indicate that all isolates are closely related.

The isolates were collected in outpatient and inpatient healthcare settings in California, Colorado, Connecticut, Florida, New Jersey, New Mexico, New York, Nevada, Texas, Utah, and Washington. The isolates were associated with multiple different infection types, including eye infections, and colonization. Patient outcomes include permanent vision loss and one death from a bloodstream infection.

Review of common exposure among patients revealed that most patients used artificial tears prior to the identification of VIM-GES-CRPA infection or colonization, with EzriCare Artificial Tears the most commonly used brand. Lab testing of the product by the CDC identified the presence of VIM-CRPA in opened bottles.


@pbleic   Jan 30
Well-written and accurate. In case you missed it, the FDA is now recommending 3 tests (if none are positive), 48 hrs. apart.
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New #microfluidic device for detecting #SARSCoV2 --can be used for Point-Of-Care testing, rapid (10") diagnostic
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Computer model predicts who will recover from COVID-19

Scientists have tracked the detailed biology and biochemistry of people infected with COVID-19 to reveal exactly how our bodies respond to the disease—and have built a predictive model to identify individual chances of recovery. -- bur relies on tests not commonly done.

Drugs and Vaccines:

Tuberculosis vaccine does not protect elderly against COVID-19, finds large Dutch study

The tuberculosis vaccine (or BCG vaccine) does not protect the elderly with co-morbidities against disease symptoms caused by a coronavirus infection. This was reported in the BCG-PRIME study which was initiated during the early days of the coronavirus pandemic when no vaccines against the virus were available.

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@EricTopol 1/31/23
The 1st results for the @BharatBiotech nasal vaccine (BBV154, approved in India) randomized trial vs shots now posted, superior antibody and cellular immune response (vs ancestral and Omicron); 4-fold less side effects
Data posted is for immune response and side effects only; await more on infections
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" Rates of #COVID-19 Cases and Deaths by Vaccination Status

Across all ages, the #bivalent #booster works.

12.7x lower death with bivalent booster compared to #unvaccinated person.

2.4x lower death with bivalent booster compared to vaccinated people without the booster."

Devices and Masks:

@masknerd made a compelling video about why it's not really worth worrying about N95 vs N99/P100 masks, the mask fit is far more important (the tables and analysis starting around 8:25 are especially useful):

Above k94 ratings, the mask that you are actually comfortable wearing AND seals tightest to your face is going to provide you the best protection.

Epidemiology/Infection control:

@Vaccinologist   Jan 31
#COVID19 has become the 8th most common cause of death among #children in the #UnitedStates, according to a study in @JAMANetworkOpen. “death rate – about 1 for every 100,000 children ages 0-19 ranks 8th vs 2019” and “5th among adolescents ages 15 to 19.”

Tips, general reading for public:






The rich are continuing #COVID precautions like requiring masks & tests, indoor air cleaning infrastructure, & priority access to vaccines & treatments. But they're telling the rest of us the pandemic is over because they think protecting the working class will cut their profits.

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@KayKosmos   Jan 22
Moderna's Covid vaccine costs $2.85 to produce. They plan to hike it to $130, making a 4000% profit.
This Covid vaccine was developed with public funding. We have to break up big pharma's monopoly control on vital meds. Stop The Greed. #FreeTheVaccine
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@ewarren  Jan 31
After getting taxpayer help to develop a COVID-19 vaccine, Moderna made $12 billion in net income in 2021 and juiced their CEO’s pay by 41%. Now apparently they’re considering quadrupling the vaccine price, up to $130 a dose. Corporate greed can’t come before public health.
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@mdc_martinus   Jan 25
However… “It is strange that so many..understand to a small extent the theory of ventilation, but practically ignore it absolutely..It is not uncommon to see a body of physicians in scientific session in a room the atmosphere of which is almost unbearable.” W.B. Canfield, 1892
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@PeterHotez   Feb 3
5/10: Even if and when we get on the other side of Covid, guess what…a 4th major coronavirus is percolating among bats and will be jumping to humans to ignite another epidemic/pandemic. The point is SARS MERS COVID19, get ready for COVID25, 26, or 27
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Former President Donald Trump takes Fifth more than 400 times in deposition, per video obtained by @KaraScannell, saying he will decline "to answer the questions under the rights and privileges afforded to every citizen under the United States Constitution."
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Privacy alert:

U.S. border officials copy the contents of up to 10,000 phones and computers every year and save them to a big database for 15 years, as we first reported in September:

Following pressure from Sen. Wyden, the agency, CBP, now says it's considering shrinking that 15-year save time and plans to give people more details about what they're doing:

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@mimms   Feb 2
Sens. Joe Manchin and Ted Cruz are teaming up on legislation that would bar the Consumer Product Safety Commission from using federal funding to ban new or existing gas stoves, according to a copy of the bill first shared with @scottwongDC
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@steve_vladeck  Feb 2
The Fifth Circuit strikes again: Unanimous panel (Jones, Ho, Wilson) strikes down the federal statute prohibiting possession of firearms while subject to a domestic violence-related restraining order; holds it violates the Second Amendment under Bruen:
It strains analogies to discard past laws disarming dangerous folks, but this is the key: the founders didn't care abt Domestic Violence, so modern laws cant.
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Black History Month begins with Republicans disbanding the subcommittee on civil rights and civil liberties.
They never miss an opportunity to tell you EXACTLY what they are.

@duty2warn   Feb 2
Outside the public’s knowledge, firms that put hundreds of thousands of dollars into the Roberts’ household are arguing cases before the Roberts Court. Roberts’ wife has made millions in commissions placing lawyers at firms that argue before SCOTUS.
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Abortion/Reproductive rights:
Minnesota Gov. Walz signed a bill codifying reproductive rights, including the right to abortion, into Minnesota state law.
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@katekilla   Feb 1
The problem with the Catholic church providing healthcare is that they can also deny it — and in places where they are literally the only option, they can effectively deny reproductive rights even in states where the law doesn't.
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RT @GermHunterMD
I am sickened that scientific and medical societies continue to hold national/international conferences in US states where pregnant delegates must risk their lives should a complication occur

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MUST READ: This is bad!
A case before a Trump-appointed federal judge in Texas is challenging the FDA's approval more than 20 years ago of the abortion drug mifepristone.(NPR)
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@jason_koebler   Jan 23
Would you believe that egg prices are higher because a giant company decided they could make more profit by raising prices and blaming "bird flu" and "inflation" rather than anything to do with bird flu or anything else
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@lyzl   Jan 31
The Iowa GOP wants parents to report teachers for teaching "divisive concepts" like the fact that racism exists.
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@daithaigilbert   Jan 29
Inside a Nazi homeschooling group run by the Lawrences, a couple from Upper Sandusky, OH, and parents of four young children. The group has almost 2,500 member and the founders say its aim is "making sure that children become wonderful Nazis” 1/6
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@FLHAmerica   Jan 22
"I don’t want to hear you say, 'Honey, I’m behind you.' Well, move. I don’t want you back there because you could be 200 miles behind. I want you to say, 'I’m with you.' And we’ll go up this freedom road together."
- Fannie Lou Hamer, activist and humanitarian (b.1917-d.1977)
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@CREWcrew  Jan 27
This is so bad: after Ginni Thomas’s emails and the work of the Cyber Ninjas went public, Arizona Republicans shielded legislators from the state’s open-records law
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Not Florida, but Orange County, California

Unable to burn digital books, Orange Unified School District bans the whole virtual library

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FACT: Permitless carry does not make you safer. States that allow concealed carry have higher gun homicide rates. DeSantis’ bill would remove: -background checks -instruction -training+oversight
And he’s proposing it near the 5th anniversary of Parkland
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@GiffordsCourage   Jan 30
Permitless carry means more guns in public spaces. It means fistfights would turn into gunfights. Permitless carry has been bad for Texas. And it would be bad for Florida.
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@duty2warn   Feb 1
The white residents of the Villages who voted twice got fines while 20 black people in the same state were arrested for voting illegally when they were legally registered. There’s two justice systems in Florida.
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A staunchly illiberal politician is ruthlessly pursuing his authoritarian agenda. Yet what the New York Times wants us to take away from the situation in Florida is that he’s taking on the “establishment” and successfully building “his brand.”

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On top of the penalties and fines the teacher becomes a felon… if a teacher gives a kid an unapproved by republicans book they will be stripped of their right to vote, their right to own firearms and their ability to obtain a reasonable job.

If the book mentions LGBT issues could they also be labeled a sex offender? Not yet - but they’re just getting started.

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Florida is basically 1930's Germany with theme parks
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@hahnscratch   Feb 1
Organ harvesting from prisoners in exchange for lessened prison sentences. I don't know what to say because I'm so utterly floored at the monstrosity of such a thought.
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@LizSzabo   Feb 3
How Tennessee axed millions in HIV funds amid scrutiny from far-right provocateurs
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Not content with working to outlaw the sale of EVs in Wyoming, the state is also declining IIJA funding to build out a network of EV chargers on their highways. It's an 80/20 match program, with the feds providing $108 million, but Wyoming doesn't want it. EVs are plainly going to comprise a majority of consumer auto sales within a few short years. Wyoming declaring that they don't want people to be able to drive EVs in or through Wyoming certainly is a decision.

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Warning from @keribla   Feb 2

For my first story @latimes, I went to Mexico and got drugs. Specifically, @ConnorASheets and I went to pharmacies, got pills & tested them. Turns out, some are selling oxy & Adderall over the counter – but the pills are actually fentanyl & meth.
In total, we tested 17 pills – things sold as hydrocodone, oxycodone, Adderall - and found 71% tested pos. for fentanyl or meth. TO BE CLEAR, these are laced pills being sold *in pharmacies* in Mexico, including tourist cities like Cabo.
And although we tested in 3 cities, a team of researchers used an infrared spectrometer to test 45 pills in 4 cities & found similar results. And when I say "similar" I mean they also found pills that actually contained heroin.
And here's the thing: It's been known for years that fentanyl has infiltrated street drugs supplies, both powder and pills. But, generally, people believed the pharmacy supplies were safe.
Predictably, this has potentially deadly consequences: If people go to Mexico for vacay or straight-up medical tourism, and THINK they're getting Percocet but actually they're getting fentanyl... it could be really easy to overdose.

Feel good du jour:

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Bits of beauty:


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